Ferrous Ferric Chloride Stimulates the Skin Cell Function and Hair Growth in Mice

Tomohisa Hirobe

It is not known whether FFC stimulates the proliferation and differentiation of mammalian skin cells as well as hair regrowth in vivo. To answer this question, FFC-containing skin lotions (FFC Super Essence Plain® and Moisture® Type, Akatsuka Co.) were painted on the dorsal skin of newborn C57BL/10JHir (B10) mice and tested for their proliferation- and differentiation-stimulating effects on keratinocytes, fibroblasts, and melanocytes as well as for their stimulating effects on the hair growth. This treatment stimulated the proliferation and differentiation of epidermal keratinocytes, dermal fibroblasts, and epidermal and dermal melanocytes in the skin as well as hair regrowth. From 2 to 3 weeks after birth B10 mice generally lose their hairs except those on the head at the telogen stage of the hair growth cycle. The treatment with FFC inhibited the alopecia hair-loss. FFC can stimulate hair regrowth, and, in addition, can inhibit the alopecia hair-loss.

Edited for hair loss treatment blog