Biol Trace Elem Res. 2010 Jan 5

Fluorine-Induced Apoptosis and Lipid Peroxidation in Human Hair Follicles In Vitro.
Wang ZH, et al

edited for hair loss treatment blogs

Fluoride is an essential for human body; however, exposure to high amounts of fluoride is correlated with hair loss. To date, little is known about the mechanism(s) of how fluoride affects hair follicles. Here, we demonstrated that sodium fluoride (NaF) significantly inhibited hair regrowth, but low NaF showed little influence. Moreover, treatment with high levels of NaF resulted in a marked increase in terminal dUTP nick end labeling-positive cells in the outer layer of the outer root sheath, the dermal sheath, and the lower bulb matrix surrounding dermal papilla. Furthermore, the enhanced apoptosis was coupled with an increased oxidative stress manifested as higher malondialdehyde content. Additionally, the presence of selenium considerably antagonized the effects of middle NaF on hair follicles, with regard to either the suppression of hair regrowth or the induction of oxidative stress and apoptosis. In conclusion, exposure to high levels of fluoride compromises hair regrowth…. .