J Cosmet Dermatol.2009;8:83

Pattern hair loss and its treatment in males:
El-Domyati M, et al

Male pattern hair loss is a common disorder of hair, resulting from genetic, endocrine, and aging factors leading to follicular miniaturization. Inflammation is a potential player in this process. AIMS: To study the histopathological and ultrastructural changes occurring in male androgenetic alopecia (AGA) or pattern hair loss. Patients/methods Fifty-five subjects were included in this study. Skin biopsies were subjected to examination, staining for collagen I and ultrastructural study. The frontal balding area showed an increase in telogen hairs and a decrease in anagen/telogen ratio and terminal/vellus hair ratio. Follicular inflammation was almost a constant feature and showed a significant inverse correlation with perifollicular fibrosis. Follicular inflammation plays a role in pattern hair loss in early cases. Over time, thickening of perifollicular sheath takes place due to increased deposition of collagen. This produces fibrosis, and sometimes complete destruction of the affected follicles in advanced cases of hair loss.

Edited for Hair regrowth blog

Hair loss treatment and hair regrowth